His club announced on Monday night that Pietrangelo needs "to nurse a minor injury and prepare for the rest of the regular season".
Hours after the announcement, Pietrangelo played in Vegas' match against Florida and had over 24 minutes of ice time.
Alex Pietrangelo is one of the Canadian team's most accomplished players with two Stanley Cup wins and an Olympic Games gold medal. He has also won the World Championship with Canada.
Pietrangelo has scored 25 points, 3 goals and 22 assists, in 47 matches so far this season.
The Four Nations starts on the night of February 13 and Canada meets Sweden in the premiere match in Montreal.