Last week, the US president threatened 25 percent tariffs on European cars and trucks, expressing dissatisfaction that the EU has not yet finalized last year's trade deal.
Macron has called Trump's moves "destabilizing," according to the AFP news agency. If the threats become reality, the EU could use its so-called instrument against economic coercion (ACI), the French president says.
The "trade bazooka", as the measure is popularly called, can include import and export restrictions, punitive tariffs, and the exclusion of foreign companies from public procurement in the EU, and is seen as a powerful weapon.
EU Commission President Ursula von der Leyen has also responded to Trump's speech.
"We are ready for all scenarios," she said at a press conference after a meeting with the Prime Minister of Armenia in Yerevan.
The work of approving the US deal is still ongoing in the EU, where the Council of Ministers and Parliament are expected to negotiate on Wednesday.
In Brussels, at the same time, Finance Minister Elisabeth Svantesson (M) sighed heavily over Trump.
"I just feel incredibly tired. It's hard to take him seriously in the end," Svantesson said.
