The broad-based S&P 500 index lost 0.2 percent, the Dow Jones industrial average lost 0.8 percent and the tech-heavy Nasdaq composite index lost 0.1 percent.
JPMorgan Chase, which kicked off the reporting season on Wall Street, reported profit and revenue figures that fell short of analysts' forecasts. The stock fell 4.2 percent, making it one of the market's worst declines.
Another loser was Delta Air Lines, which fell 2.4 percent. The airline's profit in the final quarter of last year was higher than expected, but its sales fell short of expectations.
Moderna rose. The stock surged 17 percent, the most in the S&P 500, after the company raised its sales forecast at an industry conference for analysts.
