Donald Trump has twice paused the sanctions, which were imposed during the time of former leader Bashar al-Assad in power, since Syria's new leader Ahmad al-Sharaa took office, but now they are being stopped completely.
The decision was voted through by senators from both parties.
"It is a crucial step to give the Syrian people a real chance at reconstruction after decades of unimaginable suffering," said Democrat Jeanne Shaheen, the party's top ranking member on the Senate Foreign Relations Committee.
Earlier this year, sanctions were also lifted against al-Sharaa himself. He was the leader of the Islamist rebel group HTS that led the overthrow of former President Bashar al-Assad in December last year.
The movement, which was linked to al-Qaeda, has been officially dissolved, but its members have been incorporated into the new state apparatus. The US lifted its terrorist designation in July of this year and the UN lifted its sanctions against al-Sharaa in November.
