This concerns two judges from France and Canada, respectively, as well as two prosecutors from Fiji and Senegal.
"The court is a national security threat," says US Secretary of State Marco Rubio in a statement.
He further claims that the ICC is used as an "instrument for legal warfare against the US and our close ally Israel".
The French judge Nicolas Guillou is responsible for the case in which an arrest warrant has been issued against Israel's Prime Minister Benjamin Netanyahu.
The two prosecutors are said to have "supported" the ICC's actions against Israel.
The Canadian judge Kimberly Prost has in turn been involved in a case where American soldiers have been investigated for crimes during the war in Afghanistan.
In June, four of the court's other judges were sanctioned.
In February, the Donald Trump administration imposed sanctions on the ICC's chief prosecutor Karim Khan after allegations of "illegitimate and baseless attacks" on Israel.
The sanctions mean that the individuals are prohibited from traveling to the US and may have any assets in the country frozen.
