Hereford, Altrincham, Wrexham, Sutton United, Walsall, Blyth Spartans and Lincoln are some of the clubs that can call themselves "giant killers" during the cup's 155-year history.
Macclesfield has been added to the list.
Wild scenes followed the sensational upset in the third round as supporters of the club flooded onto the pitch to celebrate with the players and manager John Rooney.
Wayne Rooney's little brother
Yes, the name will be familiar. John is the younger brother of Wayne Rooney, the former England international and Manchester United goalscorer.
Team captain and goalscorer Paul Dawson, with an ill-fitting bandage around his forehead, was carried around by fans.
To further show the magnitude of the upset:
+ As recently as last spring, Premier League club Crystal Palace celebrated its biggest success with a final victory over Manchester City at Wembley.
+ There is a gap of 117 places between the clubs in the league system.
Crystal Palace manager Oliver Glasner turned his back on the pitch in despair when Isaac Buckley-Ricketts scored the 2-0 goal after an hour at Moss Lane, the small stadium packed to the rafters.
Glasner was hardly the only one who couldn't believe his own eyes.
Although he rested some regular players, the team he put together contained several international players, such as England's Marc Guehi and Adam Wharton.
What shouldn't have happened, happened.
The club was liquidated
The town of Macclesfield, between Manchester and Stoke-on-Trent, has a long football tradition, but in recent years it has mostly experienced setbacks.
The predecessor Macclesfield Town was liquidated as recently as September 2020. A month later, businessman Robert Smethurst purchased the assets and formed Macclesfield FC.
The club was expelled from the National League and had to start over in the North West Counties Football League in the fall of 2021.
You can't get any lower in the English football pyramid.
Since then, the club has worked its way up and is currently in 14th place in the National League North, corresponding to the sixth tier of the English league system.
