In connection with the visit, al-Sharaa is expected to meet with US President Donald Trump and sign an agreement that will see Syria join a US-led coalition against the terrorist movement ISIS.
According to a source to the AFP news agency, the leaders are also expected to discuss plans for a US military base near the Syrian capital Damascus.
The visit comes days after terror-related sanctions against al-Sharaa were lifted, following a vote in the UN Security Council.
In connection with the interim president's trip to the United States, reports are coming of raids against IS cells in Syria. In total, Syrian security forces are said to have carried out 61 raids, resulting in 71 arrests, Reuters reports, citing Syrian state television.
It is the first time a Syrian leader has visited the White House since Syria became independent in 1946, according to AFP.
Ahmed al-Sharaa was the leader of the Islamist rebel group HTS which led the overthrow of former President Bashar al-Assad in December last year.
The movement, which was linked to al-Qaeda, has officially disbanded. The United States lifted its terrorist designation of the group in July of this year.
