It was during the second-to-last stage that Simon Yates decided the competition, in the climb up Colle delle Finestre.
There, Yates made sure to pass overall leader Isaac Del Toro and take the lead with almost four minutes ahead of the 21st and final stage in Rome.
The 21-year-old Mexican did not manage to catch up with the Briton on the last day.
I'm incredibly proud of the whole team. It's been three fantastic weeks. This was a decisive moment in my career, says Yates in the victory interview in Max.
Yates has won Spain around. He was on his way to take home the Giro in 2018, but failed then in the final climb.
Before the final stage, the 159 cyclists were blessed by Pope Leo XIV before pedaling away through the Vatican's gardens behind St. Peter's Church.
You are role models for young people all over the world. May God be with you during the last part of the Giro d'Italia, said the Pope.