Meta reported a quarterly profit of $2.7 billion, a figure that the tech giant said was sharply reduced due to a one-time tax. The stock plunged more than 11 percent.
IT giant Microsoft also fell, down 2.9 percent, despite the company exceeding market forecasts in its report. On the other hand, Alphabet, the owner of search giant Google, rose 2.5 percent.
Another winner was pharmaceutical giant Eli Lilly, which reported better-than-expected results, with shares rising 3.8 percent.
The significantly smaller pharmaceutical company Metsera surged 22.1 percent after competitors Novo Nordisk and Pfizer began a bidding war for the company.
The broad S&P 500 index fell 1.0 percent, the Dow Jones industrial average fell 0.2 percent and the Nasdaq's technology-heavy composite index fell 1.6 percent.
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