The Swedish national team striker nodded powerfully in front of the home crowd to 1–0 already in the 12th minute.
It was the third match in a row that Alexander Isak scored a goal, including the league cup goal in the winning match against Chelsea last week.
He also scored a goal against Chelsea in the league last weekend, but then it was still a loss.
Newcastle thereby broke a five-match losing streak and took a necessary three-pointer to try to reduce the gap to a European spot. The team was only 12th before the weekend's round.
It was a tight match where scoring opportunities were few.
Neither of the teams created many scoring opportunities. There are small margins in the Premier League. Today it was about heart, determination, will, and quality as well, said Howe according to Sky Sports.
"Look at ourselves in the mirror"
For Arsenal, the loss was costly, and the London team's hunt for their first league title since 2004 looks tough.
The team has already lost 12 points after ten rounds and is five points behind leading Manchester City, which plays later in the afternoon.
"The Gunners" were also weak offensively and had trouble creating sharp scoring opportunities.
Arsenal's injury crisis had eased somewhat before the meeting with Newcastle, but team captain Martin Ødegaard is still missing.
We can talk about Ødegaard as long as we want, but we don't have him now. But we have other answers on how we can create opportunities. We must look at ourselves in the mirror and move on, said manager Mikel Arteta.
Positive for the national team
Alexander Isak is now up to three goals in the Premier League.
When Viktor Gyökeres is also in top form in Portugal, it's a boost for national team coach Jon Dahl Tomasson ahead of the Nations League showdown later in November.
Sweden meets Slovakia on November 16 and Azerbaijan three days later at the national arena in Solna.
Alexander Isak missed the last national team gathering due to a broken toe, but has quickly found his scoring form after the injury.