In addition to the couple, several others were injured when residential buildings and civilian infrastructure were attacked, according to Ukrainian authorities.
At least two two-story houses were reportedly destroyed and a three-story building was hit in the Russian attack.
Odesa has been subjected to several deadly Russian attacks in April, the worst was in the middle of the month, when nine people were killed after an apartment building was destroyed.
In a drone attack in the frontline region of Kherson on Friday night, two more people were killed - an elderly man and a still unidentified woman.
