"The humanitarian sector was already underfunded, overstretched and literally under attack. Now we are facing a wave of brutal cuts", writes Ocha chief Tom Fletcher in a letter to employees.
The UN agency has today over 2,000 employees.
A strongly contributing reason to the redundancy demands is President Donald Trump's drastic cuts to the American aid agency USAID – the world's largest aid donor, accounting for 42 percent of all global financing of humanitarian aid.
The savings imply that the organization reduces its presence in a number of countries.
The UN refugee agency UNHCR has previously announced that it expects a "significant reduction" of staff for the same reason.