Deniz Göktas, 32, was arrested upon landing at Istanbul airport on Thursday. He is suspected of “publicly insulting religious values” during one of his shows.
The show in question is 90 minutes long and has received nine million views on YouTube.
The show satirically portrayed political developments in Turkey. The comedian also commented on President Recep Tayyip Erdogan and his imprisoned political rival, Istanbul Mayor Ekrem Imamoglu, whose arrest last year sparked massive street protests, AFP writes.
The comedian's arrest comes at a time when authorities have stepped up crackdowns on people considered critical of Turkey's conservative government or its values.
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