Oscar Piastri, teammate of Norris, took third place.
Antonelli, who leads the World Championship, started from pole position at the Miami International Autodrome, but he quickly lost the lead at the chaotic start to Monegasque Charles Leclerc of Ferrari.
The Italian gradually regained the lead and held it for the rest of the race.
Today's race was brought forward by a few hours due to the risk of heavy rain.
The next World Championship event is in Montreal on May 24.
