The away team led 1–0 at halftime and could early in the second half extend to both 2–0 and 3–0.
The 3–0 goal was scored by Salma Paralluelo, who was a major contributing factor when Spain won the World Championship gold in 2023.
With ten minutes left to play, Wolfsburg reduced the score to 1–3 when Janina Minge scored.
But as the clock approached 90 minutes of play, Fridolina Rolfö assisted Sydney Schertenleib to set the final score at 4–1, and the rout was a fact.
Both Fridolina Rolfö and Rebecka Blomqvist were substituted in with 20 minutes left to play.
The return match will be played next Thursday in Barcelona.
In tonight's late match, Manchester City won 2–0 against Chelsea.
The big difference between the teams was the Dutch star Vivianne Miedema. The former Arsenal player came on at halftime and scored both goals for the home team.
Johanna Rytting Kaneryd started on the bench for Chelsea and was substituted in in the 59th minute. Chelsea will get the chance to try to turn the double meeting around at home next Thursday.