The 2–1 win against Brentford significantly cemented a top 5 finish in the Premier League, which means play in the European club competition.
With 61 points, United are three points ahead of Liverpool and Aston Villa in the fight for third place.
Liverpool await on Sunday at Old Trafford.
Casemiro and Benjamin Sesko put United 2-0 up after a first half in which Brentford had several chances to level the score, with Mathias Jensen's equaliser coming with minutes remaining.
Bruno Fernandes played a role in Sesko's goal and is now just one assist away from matching the assist record (20) in a season, shared by Thierry Henry and Kevin De Bruyne.
