The 20-year-old midfielder injured herself in the top meeting with Häcken last week and was carried out on a stretcher.
Now Malmö FF writes on their website that Skoog has played out for the year: "After investigation, the prognosis unfortunately is that she will miss the rest of the season".
Tuva Skoog has made seven goals and nine assists during a strong season with the newcomer who surprisingly is in the gold struggle.
MFF is in third place, four points behind leading Häcken and three behind second-placed Hammarby.
Five rounds remain to be played and Malmö meets the second-to-last Linköping at home in their upcoming match on Saturday.