A shock that makes the situation even more precarious for big club Tottenham.
The unexpected three-pointer against the league's third-placed team means Leeds are now six points clear of the relegation zone, and Tottenham are now six points clear with six rounds remaining.
Noah Okafor struck twice in the first half-hour of the match. The scare was further compounded when the home team's Lisandro Martinez was shown a straight red card in the 56th minute for pulling Dominic Calvert-Lewin's hair.
Although Casemiro reduced the deficit in the 69th minute, Leeds were able to hold on to their first league victory at Old Trafford since 1981.
Tottenham's closest lifelines in the table are West Ham, two points ahead in 17th place, and Nottingham, three points ahead in 16th place.
