The statement from Iran's UN delegation comes after US President Donald Trump threatened "very strong intervention" if the regime began hanging detained protesters.
The Iranian delegation wrote on X that Washington's approach "will fail once again."
"US fantasies and policies towards Iran are rooted in regime change, where sanctions, threats, staged unrest and chaos serve as the modus operandi to create a pretext for military intervention," it further states.
In an interview on Tuesday, Trump reacted to reports that protesters had been sentenced to death by hanging.
"We don't want what's happening in Iran to happen. When they start killing thousands of people, and now I hear about hangings, we'll see how it ends for them. It's not going to go well (for the regime)," he said.
A few hours earlier, the president had written to the Iranian people in a post on Truth Social: "Help is on the way."
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