Barbara Leaf, a long-time diplomat and Middle East expert, former Syria envoy Daniel Rubinstein and the government's hostage negotiator Roger Carsten will meet with Syria's transitional leader, according to the US State Department.
This includes various groups, including members of civil society and activists, adds the Ministry of Foreign Affairs. The purpose is to get a picture of their "vision for the country's future and how the US can support them", states a statement.
This is the first formal American diplomatic visit to Syria since the US closed its embassy in Damascus in 2012.
At the same time, reports are emerging that two Turkish journalists have been killed by a Turkish drone in northern Syria. The journalists were in the area to cover clashes between Turkish-backed militias and US-backed Kurds, according to journalist groups.
The information is supported by the London-based Syrian Human Rights Observatory.
The Turkish Journalists' Association condemns the deadly attack, claiming it was intentional.