The accident occurred at around 5 a.m. local time and led to the partial collapse of a residential building in the Gul Rana district. Children are among the dead.
The explosion is believed to have been caused by a gas leak, according to police.
"The gas leak caused an explosion that destroyed part of the building," Faheem Ashraf, a spokesman for the fire service, told EFE.
Search and rescue operations continue at the scene.
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