Navone's 7-6 (7-5), 5-7, 4-6, 6-2, 6-1 victory ended Djokovic's latest bid to win a record-breaking 25th Grand Slam title. Mariano Navone is ranked 48th.
"I think it was obvious that it was a terrible feeling for me out there on the court," said Djokovic, who vomited several times and then had a cramp.
It's something I've carried with me pretty much every game. Vomiting is a serious problem there. Then my body starts to collapse; cramps and pain.
Djokovic has won 78 first-round matches at Grand Slam tournaments so far. The loss ends that winning streak. He last lost in the first round in 2006, according to AFP.
