"A total of 21 people were killed in the capital and 134 injured", Ukraine's state emergency service reports on Telegram.
16 of the bodies were found in the rubble after a nine-storey building in the Solomianskyj district.
According to Volodymyr Zelenskyj, Russia fired 32 missiles and 440 drones in Tuesday's attack on several areas in Kyiv.
"One of the most horrific attacks" on the capital during the war, the president stated.