The match was played in Bodø, 90 kilometres north of the Arctic Circle. After going into half-time tied at 1–1, the home team took the lead with two goals in quick succession from Jens Petter Hauge and Kasper Høgh after just over an hour of play.
The return leg will be played in Milan next Tuesday.
In Wednesday's second Champions League round of 16, Newcastle won 6–1 away to Qarabag, while Leverkusen beat Olympiacos 2–0 away and Club Brugge drew 3–3 with Atlético Madrid.
Corrected: The previous version contained incorrect information about which stage the tournament is in.
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