The match was played in Bodø, ninety kilometres north of the Arctic Circle. After the teams went into half-time level at 1–1, the home team took the lead with two goals in quick succession from Jens Petter Hauge and Kasper Høgh just after the hour mark.
The return leg will be played in Milan next Tuesday.
In Wednesday's second Champions League round of 16, Newcastle won 6–1 away at Qarabag, while Leverkusen beat Olympiakos 2–0 away and Club Brugge drew 3–3 with Atlético Madrid.
