Previously, Elche (5-0), Athletic Bilbao (2-0) and Rayo Vallecano (5-2) have had a taste of Barcelona's strong start to the season.
On Sunday it was Valencia's turn. Superstar Lamine Yamal scored two goals and the scoring was completed by goals from Fermin Lopez, Raphinha and Pedri.
The Catalans have scored a whopping 17 goals in the opening four rounds.
Worst rivals Real Madrid suffered their first loss of the season on Friday away to Real Betis after Kylian Mbappé missed a penalty in stoppage time.
Barcelona have won La Liga in the last two seasons and have a Swedish element in the squad in the form of 20-year-old Roony Bardghji, who has a cruciate ligament injury.
What do you think?